Phosphine is a highly toxic substance, which is mainly inhaled into the body through the respiratory tract. Into the body of phosphine through the blood distribution to the body of various organs and tissues, of which the liver, kidney, spleen content is the highest. Phosphine in the body by metabolic decomposition, and ultimately in the form of inorganic phosphorus and phosphate excreted. A small amount of phosphine in the prototype of the lungs exhaled.
The toxic effect of phosphine is mainly to damage the central nervous system and liver, kidney, heart and other solid organs. It acts on the cell's respiratory enzymes, inhibit the activity of cytochrome oxidation, so that cells occur asphyxia, resulting in cell metabolism disorders.
Phosphorus poisoning is characterized by its inhalation without irritation of the respiratory mucosa and directly lead to acute poisoning death. Inhalation of phosphine caused by acute poisoning, more inhalation after 1 to 3 hours of onset, the individual in the long 24 hours after the onset. Poisoning after the symptoms, the light when uncomfortable, chest pressure, sternal pain, cough, dizziness, tinnitus, difficulty breathing, head numbness, head pain, loss of appetite, sudden fall, etc. Spasm, difficulty walking, pupil expansion, lung and bronchial congestion and bleeding, internal organs of fat accumulation, pulmonary edema and so on within 24 hours of death.
Long-term exposure to low concentrations of phosphine can occur dizziness, headache, insomnia, weakness, nausea, loss of appetite, dry nose, loss of smell and other symptoms.
Inhaled phosphine in patients should be quickly transferred to non-polluted areas, rest and keep warm and comfortable. For weak or stopped breathing, should be immediately carried oxygen or artificial respiration, to the cardiac, taking sugar and tea and coffee. Cough can take codeability.
Security
Work can not reveal the skin. Ventilate to keep the air fresh and dry. Gas cylinders should be stored in a cool dry and well ventilated place, away from heat and fire, the best outdoor storage. Equipment pipeline available helium leak detector, soap and water leak. Should be equipped with emergency treatment supplies.
Pure PH3 is non-corrosive to common metal materials, but aluminum, aluminum and copper should not be used under normal conditions. Can use carbon steel, stainless steel, Monel, nickel-based alloy, polytetrafluoroethylene, polytrifluoroethylene vinyl polymer, vinyl chloride resin, nylon, fluorinated rubber, glass, quartz, borosilicate glass. It is possible to avoid the use of flammable materials as far as possible.
When the phosphine ignition, to take into account its strong toxicity, the first consideration should be to go all out to stop the gas outflow. Fire fighting will produce explosive gas, so sometimes not necessarily good. When the fire is large, it may endanger the surroundings, in order to control the fire and reduce the ambient temperature, spray with mist water. Available extinguishing agents for foam, carbon monoxide and mist water.